Refocusing CSA during magic angle spinning rotating-frame relaxation experiments.

ABSTRACT: We examine coherent evolution of spin-locked magnetization during magic-angle spinning (MAS), in the context of relaxation experiments designed to probe chemical exchange (rotating-frame relaxation (R_1ρ)). Coherent evolution is expected in MAS based rotating-frame relaxation decay experiments if matching conditions are met (such as, ω₁ = nω_r) and if the chemical shielding anisotropy (CSA) is substantial. We show here using numerical simulations and experiments that even when such matching requirements are avoided (e.g., ω₁ < 0.5ω_r, ∼1.5ω_r, >2.5ω_r), coherent evolution of spin-locked magnetization with large CSA is still considerable. The coherent evolution has important consequences on the analysis of relaxation de

SUBMITTER: Keeler EG 

PROVIDER: S-EPMC6512962 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature