Ontology highlight
ABSTRACT:
SUBMITTER: Ellis KL
PROVIDER: S-EPMC6512969 | biostudies-literature | 2015 Feb
REPOSITORIES: biostudies-literature
The pharmacogenomics journal 20140819 1
The mechanistic effects of intravenous glucose, insulin and potassium (GIK) in cardiac ischemia are not well understood. We conducted a genetic sub-study of the Immediate Myocardial Metabolic Enhancement During Initial Assessment and Treatment in Emergency care (IMMEDIATE) Trial to explore effects of common and rare glucose and insulin-related genetic loci on initial to 6-h and 6- to 12-h change in plasma glucose and potassium. We identified 27 NOTCH2/ADAM30 and 8 C2CD4B variants conferring a 40 ...[more]