Chronic Atrial and Ventricular Pacing in the Mouse.

ABSTRACT:

Background

The mouse is the most widely used mammal in experimental biology. Although many clinically relevant in vivo cardiac stressors are used, one that has eluded translation is long-term cardiac pacing. Here, we present the first method to chronically simulate and simultaneously record cardiac electrical activity in conscious mobile mice. We then apply it to study right ventricular pacing induced electromechanical dyssynchrony and its reversal (resynchronization).

Methods and results

The method includes a custom implantable bipolar stimulation and recording lead and flexible external conduit and electrical micro-commutator linked to a pulse generator/recorder. This achieved continuous pacing for at least 1 month in 77% of implants. Mice were then subjected to cardiac is

SUBMITTER: Stahlberg M 

PROVIDER: S-EPMC6513021 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature