Predicting seizures in pregnant women with epilepsy: Development and external validation of a prognostic model.

ABSTRACT:

Background

Seizures are the main cause of maternal death in women with epilepsy, but there are no tools for predicting seizures in pregnancy. We set out to develop and validate a prognostic model, using information collected during the antenatal booking visit, to predict seizure risk at any time in pregnancy and until 6 weeks postpartum in women with epilepsy on antiepileptic drugs.

Methods and findings

We used datasets of a prospective cohort study (EMPiRE) of 527 pregnant women with epilepsy on medication recruited from 50 hospitals in the UK (4 November 2011-17 August 2014). The model development cohort comprised 399 women whose antiepileptic drug doses were adjusted based on clinical features only; the validation cohort comprised 128 women whose drug dose adjustments wer

SUBMITTER: Allotey J 

PROVIDER: S-EPMC6513048 | biostudies-literature | 2019 May

REPOSITORIES: biostudies-literature