DIGREM: an integrated web-based platform for detecting effective multi-drug combinations.

ABSTRACT:

Motivation

Synergistic drug combinations are a promising approach to achieve a desirable therapeutic effect in complex diseases through the multi-target mechanism. However, in vivo screening of all possible multi-drug combinations remains cost-prohibitive. An effective and robust computational model to predict drug synergy in silico will greatly facilitate this process.

Results

We developed DIGREM (Drug-Induced Genomic Response models for identification of Effective Multi-drug combinations), an online tool kit that can effectively predict drug synergy. DIGREM integrates DIGRE, IUPUI_CCBB, gene set-based and correlation-based models for users to predict synergistic drug combinations with dose-response information and drug-treated gene expression profiles.

Availability and

SUBMITTER: Zhang M 

PROVIDER: S-EPMC6513155 | biostudies-literature | 2019 May

REPOSITORIES: biostudies-literature