BMDExpress 2: enhanced transcriptomic dose-response analysis workflow.

ABSTRACT:

Summary

A new version (version 2) of the genomic dose-response analysis software, BMDExpress, has been created. The software addresses the increasing use of transcriptomic dose-response data in toxicology, drug design, risk assessment and translational research. In this new version, we have implemented additional statistical filtering options (e.g. Williams' trend test), curve fitting models, Linux and Macintosh compatibility and support for additional transcriptomic platforms with up-to-date gene annotations. Furthermore, we have implemented extensive data visualizations, on-the-fly data filtering, and a batch-wise analysis workflow. We have also significantly re-engineered the code base to reflect contemporary software engineering practices and streamline future development. The

SUBMITTER: Phillips JR 

PROVIDER: S-EPMC6513160 | biostudies-literature | 2019 May

REPOSITORIES: biostudies-literature