Towards region-specific propagation of protein functions.

ABSTRACT:

Motivation

Due to the nature of experimental annotation, most protein function prediction methods operate at the protein-level, where functions are assigned to full-length proteins based on overall similarities. However, most proteins function by interacting with other proteins or molecules, and many functional associations should be limited to specific regions rather than the entire protein length. Most domain-centric function prediction methods depend on accurate domain family assignments to infer relationships between domains and functions, with regions that are unassigned to a known domain-family left out of functional evaluation. Given the abundance of residue-level annotations currently available, we present a function prediction methodology that automatically infers function

SUBMITTER: Koo DCE 

PROVIDER: S-EPMC6513163 | biostudies-literature | 2019 May

REPOSITORIES: biostudies-literature