Common variation near IRF6 is associated with IFN-β-induced liver injury in multiple sclerosis.

ABSTRACT: Multiple sclerosis (MS) is a disease of the central nervous system treated with disease-modifying therapies, including the biologic, interferon-β (IFN-β). Up to 60% of IFN-β-exposed MS patients develop abnormal biochemical liver test results^1,2, and 1 in 50 experiences drug-induced liver injury³. Since genomic variation contributes to other forms of drug-induced liver injury^4,5, we aimed to identify biomarkers of IFN-β-induced liver injury using a two-stage genome-wide association study. The rs2205986 variant, previously linked to differential expression of IRF6, surpassed genome-wide significance in the combined two-stage analysis (P = 2.3 × 10^-8, odds ratio = 8.3, 95% confidence interval = 3.6-19.2). Analysis of an independent cohort of IFN-β-t

SUBMITTER: Kowalec K 

PROVIDER: S-EPMC6513312 | biostudies-literature | 2018 Aug

REPOSITORIES: biostudies-literature