End-to-End Differentiable Learning of Protein Structure.

ABSTRACT: Predicting protein structure from sequence is a central challenge of biochemistry. Co-evolution methods show promise, but an explicit sequence-to-structure map remains elusive. Advances in deep learning that replace complex, human-designed pipelines with differentiable models optimized end to end suggest the potential benefits of similarly reformulating structure prediction. Here, we introduce an end-to-end differentiable model for protein structure learning. The model couples local and global protein structure via geometric units that optimize global geometry without violating local covalent chemistry. We test our model using two challenging tasks: predicting novel folds without co-evolutionary data and predicting known folds without structural templates. In the first task, the model achi

SUBMITTER: AlQuraishi M 

PROVIDER: S-EPMC6513320 | biostudies-literature | 2019 Apr

REPOSITORIES: biostudies-literature