Production and characterization of novel ssRNA bacteriophage virus-like particles from metagenomic sequencing data.

ABSTRACT:

Background

Protein shells assembled from viral coat proteins are an attractive platform for development of new vaccines and other tools such as targeted bioimaging and drug delivery agents. Virus-like particles (VLPs) derived from the single-stranded RNA (ssRNA) bacteriophage coat proteins (CPs) have been important and successful contenders in the area due to their simplicity and robustness. However, only a few different VLP types are available that put certain limitations on continued developments and expanded adaptation of ssRNA phage VLP technology. Metagenomic studies have been a rich source for discovering novel viral sequences, and in recent years have unraveled numerous ssRNA phage genomes significantly different from those known before. Here, we describe the use of ssRNA CP

SUBMITTER: Lieknina I 

PROVIDER: S-EPMC6513524 | biostudies-literature | 2019 May

REPOSITORIES: biostudies-literature