Arsenic exposure and serum antibody concentrations to diphtheria and tetanus toxoid in children at age 5: A prospective birth cohort in Bangladesh.

ABSTRACT:

Background

Arsenic can impair immune function. Timing of exposure can influence potential immunotoxicity of arsenic exposure. We examined the association between drinking water arsenic concentrations (W-As) measured repeatedly during different exposure windows in early life and serum concentrations of IgG antibodies against diphtheria and tetanus toxoids (diphtheria and tetanus antibody).

Methods

A prospective cohort of pregnant women was recruited in Bangladesh (2008-2011). Averaged W-As levels were calculated for: pregnancy (W-As_pregnancy): ≤16 weeks gestation and <1 month; toddlerhood (W-As_toddlerhood): 12 and 20-40 months; and early childhood (W-As_childhood): 4-5 years. Serum was collected from 502 vaccinated children at age 5 and concent

SUBMITTER: Welch BM 

PROVIDER: S-EPMC6513691 | biostudies-literature | 2019 Jun

REPOSITORIES: biostudies-literature