Dopamine effects on frontal cortical blood flow and motor inhibition in Parkinson's disease.

ABSTRACT: Parkinson's disease (PD) is characterized by dysfunction in frontal cortical and striatal networks that regulate action control. We investigated the pharmacological effect of dopamine agonist replacement therapy on frontal cortical activity and motor inhibition. Using Arterial Spin Labeling MRI, we examined 26 PD patients in the off- and on-dopamine agonist medication states to assess the effect of dopamine agonists on frontal cortical regional cerebral blood flow. Motor inhibition was measured by the Simon task in both medication states. We applied the dual process activation suppression model to dissociate fast response impulses from motor inhibition of incorrect responses. General linear regression model analyses determined the medication effect on regional cerebral blood flow and motor

SUBMITTER: Trujillo P 

PROVIDER: S-EPMC6513702 | biostudies-literature | 2019 Jun

REPOSITORIES: biostudies-literature