Perturbations of the arginine metabolome following exposures to traffic-related air pollution in a panel of commuters with and without asthma.

ABSTRACT:

Background

Mechanisms underlying the effects of traffic-related air pollution on people with asthma remain largely unknown, despite the abundance of observational and controlled studies reporting associations between traffic sources and asthma exacerbation and hospitalizations.

Objectives

To identify molecular pathways perturbed following traffic pollution exposures, we analyzed data as part of the Atlanta Commuters Exposure (ACE-2) study, a crossover panel of commuters with and without asthma.

Methods

We measured 27 air pollutants and conducted high-resolution metabolomics profiling on blood samples from 45 commuters before and after each exposure session. We evaluated metabolite and metabolic pathway perturbations using an untargeted metabolome-wide association stud

SUBMITTER: Liang D 

PROVIDER: S-EPMC6513706 | biostudies-literature | 2019 Jun

REPOSITORIES: biostudies-literature