Chronic + binge alcohol exposure promotes inflammation and alters airway mechanics in the lung.

ABSTRACT:

Introduction

Alcohol use disorders are major risk factors for the development of and susceptibility to acute respiratory distress syndrome. Although these risks of alcohol consumption on the lung are well described, mechanisms by which alcohol abuse promotes acute lung injury are poorly understood. These gaps in our understanding are due, at least in part, to limitations of animal models to recapitulate human alcohol consumption. Recently, a new model of chronic plus binge alcohol exposure was developed that is hypothesized to better model drinking patterns of individuals with alcohol use disorders. Specifically, this paradigm models chronic consumption coupled with periodic bouts of heavy drinking. The impacts of this alcohol-exposure regimen on the lung are uncharacterized. There

SUBMITTER: Poole LG 

PROVIDER: S-EPMC6513731 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature