Closed-loop all-optical interrogation of neural circuits in vivo.

ABSTRACT: Understanding the causal relationship between neural activity and behavior requires the ability to perform rapid and targeted interventions in ongoing activity. Here we describe a closed-loop all-optical strategy for dynamically controlling neuronal activity patterns in awake mice. We rapidly tailored and delivered two-photon optogenetic stimulation based on online readout of activity using simultaneous two-photon imaging, thus enabling the manipulation of neural circuit activity 'on the fly' during behavior.

SUBMITTER: Zhang Z 

PROVIDER: S-EPMC6513754 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature