Activity of IL-12/15/18 primed natural killer cells against hepatocellular carcinoma.

ABSTRACT:

Background

Hepatocellular carcinoma (HCC) is common, but remains difficult to treat. Natural killer (NK) cells are cells of the innate immune system that have potent anti-cancer activity. Recent work has shown that stimulation with IL-12/15/18 leads to the generation of NK cells with enhanced functional and putative "memory" properties. We have investigated the activity of these NK cells against HCC cell lines in vitro and in a mouse model.

Methods

NK cells from healthy donors or individuals with HCC were activated with IL-12/15/18 in vitro and tested for cytotoxic activity against a panel of human HCC cell lines. IL-12/15/18 primed murine NK cells were then infused into a murine model of spontaneously arising HCC to test for anti-tumor activity.

Results

NK cells from

SUBMITTER: Zhuang L 

PROVIDER: S-EPMC6513806 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature