Vasculogenic properties of adventitial Sca-1⁺CD45⁺ progenitor cells in mice: a potential source of vasa vasorum in atherosclerosis.

ABSTRACT: The cellular origins of vasa vasorum are ill-defined and may involve circulating or local progenitor cells. We previously discovered that murine aortic adventitia contains Sca-1⁺CD45⁺ progenitors that produce macrophages. Here we investigated whether they are also vasculogenic. In aortas of C57BL/6 mice, Sca-1⁺CD45⁺ cells were localised to adventitia and lacked surface expression of endothelial markers (<1% for CD31, CD144, TIE-2). In contrast, they did show expression of CD31, CD144, TIE-2 and VEGFR2 in atherosclerotic ApoE^-/- aortas. Although Sca-1⁺CD45⁺ cells from C57BL/6 aorta did not express CD31, they formed CD31⁺ colonies in endothelial differentiation media and produced interconnecting vascular-

SUBMITTER: Toledo-Flores D 

PROVIDER: S-EPMC6513996 | biostudies-literature | 2019 May

REPOSITORIES: biostudies-literature