Elaborations on Corallopyronin A as a Novel Treatment Strategy Against Genital Chlamydial Infections.

ABSTRACT: Ascending Chlamydia trachomatis infection causes functional damage to the fallopian tubes, which may lead to ectopic pregnancy and infertility in women. Treatment failures using the standard regimens of doxycycline and azithromycin have been observed. We tested the polyketide-derived α-pyrone antibiotic Corallopyronin A (CorA) that inhibits the bacterial DNA dependent RNA polymerase and has strong activity against various extracellular and some intracellular bacteria. Extensive testing in cell culture infection models and in an ex vivo human fallopian tube model under different oxygen concentrations was performed to assess the anti-chlamydial efficacy of CorA at physiological conditions. CorA showed high efficacy against C. trachomatis (MIC_N/H: 0.5 μg/mL for

SUBMITTER: Loeper N 

PROVIDER: S-EPMC6514060 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature