Renewed assessment of the risk of emergent advanced cell therapies to transmit neuroproteinopathies.

ABSTRACT: The inadvertent transmission of long incubating, untreatable and fatal neurodegenerative prionopathies, notably iatrogenic Creutzfeldt-Jakob disease, following transplantation of cadaver-derived corneas, pituitary growth, hormones and dura mater, constitutes a historical precedent which has underpinned the application of precautionary principles to modern day advanced cell therapies. To date these have been reflected by geographic or medical history risk-based deferral of tissue donors. Emergent understanding of other prion-like proteinopathies, their potential independence from prions as a transmissible agent and the variable capability of scalably manufacturable stem cells and derivatives to take up and clear or to propagate prions, substantiate further commitment to qualifying neurodege

SUBMITTER: De Sousa PA 

PROVIDER: S-EPMC6514076 | biostudies-literature | 2019 Mar

REPOSITORIES: biostudies-literature