Cholesterol and Cardiolipin Importance in Local Anesthetics-Membrane Interactions: The Langmuir Monolayer Study.

ABSTRACT: Local anesthetics (LAs) are known to act on membrane level; however, the molecular mechanism of their activity is still not fully understood. One hypothesis holds that these drugs can incorporate into lipid membrane of nerve cells and in this way change conformation of channel proteins responsible for transport of sodium ions. However, the action of anesthetics is not limited to nerve cells. These drugs also affect other types of cells and organelles, causing severe side effects. In this paper, we applied Langmuir monolayers-as model of cellular membranes-and investigated interactions between selected amide-type local anesthetics (lidocaine prilocaine, mepivacaine and ropivacaine, in the form of hydrochlorides) and lipid components of natural membranes: cholesterol, POPC and cardiolipin (C

SUBMITTER: Mildner J 

PROVIDER: S-EPMC6514108 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature