An Extension of the Kimura Two-Parameter Model to the Natural Evolutionary Process.

ABSTRACT: Accurate estimates of genetic difference are required for research in evolutionary biology. Here we extend the Kimura two-parameter (K2P) model by considering gaps (insertions and/or deletions) and introduce a new measure for estimating genetic difference between two nucleotide sequences in terms of nucleotide changes that have occurred during the evolutionary process. Using the nuclear ribosomal DNA internal transcribed spacer 2 region from the genus Physalis, we demonstrate that species identification and phylogenetic studies strongly depend on evolutionary models. It is especially noteworthy that the use of different models affects the degree of overlap between intraspecific and interspecific genetic differences. We observe that the percentage of interspecific sequence pairs with values

SUBMITTER: Nishimaki T 

PROVIDER: S-EPMC6514111 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature