Cumulative Effects of LDL Cholesterol and CRP Levels on Recurrent Stroke and TIA.

ABSTRACT:

Aims

To investigate the relative contribution of on-treatment low-density lipoprotein (LDL) cholesterol and C-reactive protein (CRP) to the risk of recurrent stroke and transient ischemic attack (TIA) in patients with history of ischemic stroke.

Methods

A total of 1095 patients with non-cardioembolic ischemic stroke were randomized into two groups: control and patients receiving 10 mg of pravastatin per day. After excluding 18 patients who did not have baseline CRP data, the effects of LDL cholesterol and CRP on recurrent stroke and TIA were prospectively assessed in 1077 patients.

Results

During the follow-up of 4.9±1.4 years, there were 131 recurrent stroke or TIA cases. Patients with ontreatment LDL cholesterol ＜120 mg/dL showed 29% reduction in recurrent stroke an

SUBMITTER: Kitagawa K 

PROVIDER: S-EPMC6514170 | biostudies-literature | 2019 May

REPOSITORIES: biostudies-literature