The Relationship Between Heart Rate and Left Ventricular Isovolumic Relaxation During Normoxia and Hypoxia-Asphyxia in Newborn Piglets.

ABSTRACT: Background: Many asphyxiated neonates have cardiac complications including arrhythmia and contractile dysfunction. Little is known about the relationship between heart rate (HR) and diastolic function in asphyxiated neonates. We aimed to study the relationship between HR and left ventricular (LV) isovolumic relaxation (IVR) in neonates with asphyxia using a swine model. Methods: Term newborn piglets were anesthetized and acutely instrumented with the placement of Millar^® catheter in the left ventricle. Hemodynamic parameters including HR, cardiac output, stroke volume, dP/dt_max and dP/dt_min, and IVR time constant (Tau) were continuously measured and recorded. Sixteen piglets were exposed to 50-minute normocapnic hypoxia followed by asphyxia (m

SUBMITTER: Shen W 

PROVIDER: S-EPMC6514222 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature