Multi-Omic Data Interpretation to Repurpose Subtype Specific Drug Candidates for Breast Cancer.

ABSTRACT: Triple-negative breast cancer (TNBC), which is largely synonymous with the basal-like molecular subtype, is the 5th leading cause of cancer deaths for women in the United States. The overall prognosis for TNBC patients remains poor given that few treatment options exist; including targeted therapies (not FDA approved), and multi-agent chemotherapy as standard-of-care treatment. TNBC like other complex diseases is governed by the perturbations of the complex interaction networks thereby elucidating the underlying molecular mechanisms of this disease in the context of network principles, which have the potential to identify targets for drug development. Here, we present an integrated "omics" approach based on the use of transcriptome and interactome data to identify dynamic/active protein-pr

SUBMITTER: Turanli B 

PROVIDER: S-EPMC6514249 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature