Bactericidal/Permeability-Increasing Fold-Containing Family B Member 4 May Be Associated with NSAID-Induced Enteropathy.

ABSTRACT:

Background

There is considerable individual variability in nonsteroidal anti-inflammatory drug (NSAID)-induced enteropathy.

Aim

To identify the SNP that is most significantly involved with NSAID-induced enteropathy.

Methods

One hundred fifty human subjects who were known to have a certain degree of loxoprofen- or celecoxib-induced small-intestinal damage from a previous study were enrolled. The subjects were divided into groups based on treatments and also on the increased number of small intestinal mucosal breaks. The candidate SNP was selected by an initial analysis of GWAS among the groups in various combinations. After the initial analysis, the gene including the specified SNP was analyzed in detail using GWAS and genotype imputation.

Results

After analysis

SUBMITTER: Fujimori S 

PROVIDER: S-EPMC6514250 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature