Semi-quantification and grading of amyloid PET: A project of the European Alzheimer's Disease Consortium (EADC).

ABSTRACT:

Background

amyloid-PET reading has been classically implemented as a binary assessment, although the clinical experience has shown that the number of borderline cases is non negligible not only in epidemiological studies of asymptomatic subjects but also in naturalistic groups of symptomatic patients attending memory clinics. In this work we develop a model to compare and integrate visual reading with two independent semi-quantification methods in order to obtain a tracer-independent multi-parametric evaluation.

Methods

We retrospectively enrolled three cohorts of cognitively impaired patients submitted to ¹⁸F-florbetaben (53 subjects), ¹⁸F-flutemetamol (62 subjects), ¹⁸F-florbetapir (60 subjects) PET/CT respectively, in 6 European centres be

SUBMITTER: Chincarini A 

PROVIDER: S-EPMC6514268 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature