Small-molecule inhibition of prostaglandin E receptor 2 impairs cyclooxygenase-associated malignant glioma growth.

ABSTRACT:

Background and purpose

An up-regulation of COX-2 in malignant gliomas causes excessive synthesis of PGE₂ , which is thought to facilitate brain tumour growth and invasion. However, which downstream PGE₂ receptor subtype (i.e., EP₁ -EP₄ ) directly contributes to COX activity-promoted glioma growth remains largely unknown.

Experimental approach

Using a publicly available database from The Cancer Genome Atlas research network, we compared the expression of PGE₂ signalling-associated genes in human lower grade glioma and glioblastoma multiforme (GBM) samples. The Kaplan-Meier analysis was performed to determine the relationship between their expression and survival probability. A time-resolved FRET method was used to identif

SUBMITTER: Qiu J 

PROVIDER: S-EPMC6514294 | biostudies-literature | 2019 Jun

REPOSITORIES: biostudies-literature