An osteoclastogenesis system, the RANKL/RANK signalling pathway, contributes to aggravated allergic inflammation.

ABSTRACT:

Background and purpose

As an osteoclast differentiation factor, receptor activator of NF-κB ligand (RANKL) is produced by various immune cells and may be involved in the pathogenesis of osteoporosis and inflammation. Although RANKL is expressed in most immune cells and tissues, it is not clear how this might affect allergic inflammation.

Experimental approach

The roles of RANKL in allergic rhinitis (AR) were analysed in an ovalbumin (OVA)-induced animal model, human subjects, and a human mast cell line (HMC-1). Small interfering RNA experiments were performed in an OVA-induced AR model.

Key results

RANKL and RANKL receptor (RANK) were up-regulated in serum or nasal mucosal tissues of AR patients and AR mice. RANKL and RANK were colocalised in mast cells of nasal mucos

SUBMITTER: Nam SY 

PROVIDER: S-EPMC6514295 | biostudies-literature | 2019 Jun

REPOSITORIES: biostudies-literature