Linked anatomical and functional brain alterations in children with attention-deficit/hyperactivity disorder.

ABSTRACT:

Objectives

Neuroimaging studies have independently demonstrated brain anatomical and functional impairments in participants with ADHD. The aim of the current study was to explore the relationship between structural and functional brain alterations in ADHD through an integrated analysis of multimodal neuroimaging data.

Methods

We performed a multimodal analysis to integrate resting-state functional magnetic resonance imaging (MRI), structural MRI, and diffusion-weighted imaging data in a large, single-site sample of children with and without diagnosis for ADHD. The inferred subject contributions were fed into regression models to investigate the relationships between diagnosis, symptom severity, gender, and age.

Results

Compared with controls, children with ADHD diagno

SUBMITTER: Wu ZM 

PROVIDER: S-EPMC6514365 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature