TMEM16A is implicated in the regulation of coronary flow and is altered in hypertension.

ABSTRACT:

Background and purpose

Coronary artery disease leads to ischaemic heart disease and ultimately myocardial infarction. Thus, it is important to determine the factors that regulate coronary blood flow. Ca²⁺ -activated chloride channels contribute to the regulation of arterial tone; however, their role in coronary arteries is unknown. The aim of this study was to investigate the expression and function of the main molecular correlate of Ca²⁺ -activated chloride channels, TMEM16A, in rat coronary arteries.

Experimental approach

We performed mRNA and protein analysis, electrophysiological studies of coronary artery myocytes, and functional studies of coronary artery contractility and coronary perfusion, using novel inhibitors of TMEM16A. Furthermore, we asse

SUBMITTER: Askew Page HR 

PROVIDER: S-EPMC6514379 | biostudies-literature | 2019 Jun

REPOSITORIES: biostudies-literature