Cdc42 Effector Protein 3 Interacts With Cdc42 in Regulating Xenopus Somite Segmentation.

ABSTRACT: Somitogenesis is a critical process during vertebrate development that establishes the segmented body plan and gives rise to the vertebra, skeletal muscles, and dermis. While segmentation clock and wave front mechanisms have been elucidated to control the size and time of somite formation, regulation of the segmentation process that physically separates somites is not understood in detail. Here, we identified a cytoskeletal player, Cdc42 effector protein 3 (Cdc42ep3, CEP3) that is required for somite segmentation in Xenopus embryos. CEP3 is specifically expressed in somite tissue during somite segmentation. Loss-of-function experiments showed that CEP3 is not required for the specification of paraxial mesoderm, nor the differentiation of muscle cells, but is required for the

SUBMITTER: Kho M 

PROVIDER: S-EPMC6514426 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature