Recent Developments in Metal-Based Drugs and Chelating Agents for Neurodegenerative Diseases Treatments.

ABSTRACT: The brain has a unique biological complexity and is responsible for important functions in the human body, such as the command of cognitive and motor functions. Disruptive disorders that affect this organ, e.g. neurodegenerative diseases (NDDs), can lead to permanent damage, impairing the patients' quality of life and even causing death. In spite of their clinical diversity, these NDDs share common characteristics, such as the accumulation of specific proteins in the cells, the compromise of the metal ion homeostasis in the brain, among others. Despite considerable advances in understanding the mechanisms of these diseases and advances in the development of treatments, these disorders remain uncured. Considering the diversity of mechanisms that act in NDDs, a wide range of compounds have b

SUBMITTER: Sales TA 

PROVIDER: S-EPMC6514778 | biostudies-literature | 2019 Apr

REPOSITORIES: biostudies-literature