Clinically Relevant Immune Responses against Cytomegalovirus: Implications for Precision Medicine.

ABSTRACT: Immune responses to human cytomegalovirus (CMV) can be used to assess immune fitness in an individual. Further to its clinical significance in posttransplantation settings, emerging clinical and translational studies provide examples of immune correlates of protection pertaining to anti-CMV immune responses in the context of cancer or infectious diseases, e.g., tuberculosis. In this viewpoint, we provide a brief overview about CMV-directed immune reactivity and immune fitness in a clinical context and incorporate some of our own findings obtained from peripheral blood or tumour-infiltrating lymphocytes (TIL) from patients with advanced cancer. Observations in patients with solid cancers whose lesions contain both CMV and tumour antigen-specific T-cell subsets are highlighted, due to a poss

SUBMITTER: Lerias JR 

PROVIDER: S-EPMC6514820 | biostudies-literature | 2019 Apr

REPOSITORIES: biostudies-literature