A Small In Vitro Fermentation Model for Screening the Gut Microbiota Effects of Different Fiber Preparations.

ABSTRACT: The development of prebiotic fibers requires fast high-throughput screening of their effects on the gut microbiota. We demonstrated the applicability of a mictotiter plate in the in vitro fermentation models for the screening of potentially-prebiotic dietary fibers. The effects of seven rye bran-, oat- and linseed-derived fiber preparations on the human fecal microbiota composition and short-chain fatty acid production were studied. The model was also used to study whether fibers can alleviate the harmful effects of amoxicillin-clavulanate on the microbiota. The antibiotic induced a shift in the bacterial community in the absence of fibers by decreasing the relative amounts of Bifidobacteriaceae, Bacteroidaceae, Prevotellaceae, Lachnospiraceae and Ruminococcaceae, and increasing proteobact

SUBMITTER: Tsitko I 

PROVIDER: S-EPMC6514940 | biostudies-literature | 2019 Apr

REPOSITORIES: biostudies-literature