The Roles of Electrostatic Interactions in Capsid Assembly Mechanisms of Giant Viruses.

ABSTRACT: In the last three decades, many giant DNA viruses have been discovered. Giant viruses present a unique and essential research frontier for studies of self-assembly and regulation of supramolecular assemblies. The question on how these giant DNA viruses assemble thousands of proteins so accurately to form their protein shells, the capsids, remains largely unanswered. Revealing the mechanisms of giant virus assembly will help to discover the mysteries of many self-assembly biology problems. Paramecium bursaria Chlorella virus-1 (PBCV-1) is one of the most intensively studied giant viruses. Here, we implemented a multi-scale approach to investigate the interactions among PBCV-1 capsid building units called capsomers. Three binding modes with different strengths are found between capsom

SUBMITTER: Xian Y 

PROVIDER: S-EPMC6514965 | biostudies-literature | 2019 Apr

REPOSITORIES: biostudies-literature