Genome-wide DNA methylation encodes cardiac transcriptional reprogramming in human ischemic heart failure.

ABSTRACT: Ischemic cardiomyopathy (ICM) is the clinical endpoint of coronary heart disease and a leading cause of heart failure. Despite growing demands to develop personalized approaches to treat ICM, progress is limited by inadequate knowledge of its pathogenesis. Since epigenetics has been implicated in the development of other chronic diseases, the current study was designed to determine whether transcriptional and/or epigenetic changes are sufficient to distinguish ICM from other etiologies of heart failure. Specifically, we hypothesize that genome-wide DNA methylation encodes transcriptional reprogramming in ICM. RNA-sequencing analysis was performed on human ischemic left ventricular tissue obtained from patients with end-stage heart failure, which enriched known targets of the polycomb methy

SUBMITTER: Pepin ME 

PROVIDER: S-EPMC6515060 | biostudies-literature | 2019 Mar

REPOSITORIES: biostudies-literature