Identification of CTRP1 as a Prognostic Biomarker and Oncogene in Human Glioblastoma.

ABSTRACT:

Introduction

Glioblastoma (GBM) is the most frequent and malignant type of primary brain tumors in adults. The valuable prognostic biomarkers and therapeutic targets for GBM remain to be elucidated. The association of adipokines with cancer has been well documented. The C1q/TNF-related protein 1 (CTRP1), a novel adipokine, belongs to the CTRP family.

Methods

In the present study, the expression and potential roles of CTRP1 in GBM were explored based on in silico evaluation, including GEPIA, the Pathology Atlas of the Human Protein Atlas, cBioPortal, TIMER, and SurvExpress. The CCK8, transwell, and wound healing assays were used to detect cell proliferation and migration.

Results

It was found that mRNA expression levels of CTRP1 were significantly upregulated in

SUBMITTER: Chen L 

PROVIDER: S-EPMC6515110 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature