Ranolazine prevents pressure overload-induced cardiac hypertrophy and heart failure by restoring aberrant Na⁺ and Ca²⁺ handling.

ABSTRACT:

Background

Cardiac hypertrophy and heart failure are characterized by increased late sodium current and abnormal Ca²⁺ handling. Ranolazine, a selective inhibitor of the late sodium current, can reduce sodium accumulation and Ca ²⁺ overload. In this study, we investigated the effects of ranolazine on pressure overload-induced cardiac hypertrophy and heart failure in mice.

Methods and results

Inhibition of late sodium current with the selective inhibitor ranolazine suppressed cardiac hypertrophy and fibrosis and improved heart function assessed by echocardiography, hemodynamics, and histological analysis in mice exposed to chronic pressure overload induced by transverse aortic constriction (TAC). Ca²⁺ imaging of ventricular myocytes from TAC mi

SUBMITTER: Nie J 

PROVIDER: S-EPMC6515545 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature