Ovarian dysfunction following prenatal exposure to an insecticide, chlordecone, associates with altered epigenetic features.

ABSTRACT: Chlordecone (CD) is an insecticide that was used in the French West Indies for several years to control the banana root borer pest. Given its nonsignificant degradation, it persists in the environment. CD is a carcinogenic compound with reproductive and developmental toxicity and is a recognized endocrine-disrupting chemical. In this study, we examined the effects of CD on female reproductive system of mice with the focus on epigenetic features in ovary. Our data show that gestational exposure to low dose of CD affects meiotic double-strand breaks repair in female embryos. In adult mice derived from CD-treated pregnant females, we observed delayed puberty, decreased number of primordial and increased number of atretic follicles. Gene expression analysis revealed that Rcbtb2 and Rbpms genes

SUBMITTER: Legoff L 

PROVIDER: S-EPMC6515617 | biostudies-literature | 2019 May

REPOSITORIES: biostudies-literature