Identification of genetic association between cardiorespiratory fitness and the trainability genes in childhood acute lymphoblastic leukemia survivors.

ABSTRACT:

Background

The progress of treatments of childhood acute lymphoblastic leukemia (ALL) has made it possible to reach a survival rate superior to 80%. However, the treatments lead to several long-term adverse effects, including cardiac toxicity. Although studies have reported associations between genetic variants and cardiorespiratory fitness, none has been performed on childhood ALL survivors.

Methods

We performed whole-exome sequencing in 239 childhood ALL survivors from the PETALE cohort. Germline variants (both common and rare) in selected set of genes (N = 238) were analyzed for an association with cardiorespiratory fitness.

Results

Our results showed that the common variant in the TTN gene was significantly associated with a low cardiorespiratory fitness level (p 

SUBMITTER: Caru M 

PROVIDER: S-EPMC6515640 | biostudies-literature | 2019 May

REPOSITORIES: biostudies-literature