MiRNA deregulation targets specific pathways in leiomyosarcoma development: an in silico analysis.

ABSTRACT:

Background

MicroRNA (miRNA) mediate post-transcriptional gene repression and are involved in a variety of human diseases, including cancer. Soft tissue sarcomas are rare malignancies with a variety of histological subtypes which may occur virtually anywhere in the human body. Leiomyosarcoma is one of the most common subtypes, shows a smooth muscle phenotype and its cancerogenesis is still unclear. The aim of our study was to investigate the potential role of miRNA differential expression in leiomyosarcoma development.

Methods

We first employed the Sarcoma microRNA Expression Database, a repository that describes the patterns of over 1000 miRNA expression in various human sarcoma types, to identify differentially expressed miRNA comparing leiomyosarcoma and smooth muscle samp

SUBMITTER: Benna C 

PROVIDER: S-EPMC6515658 | biostudies-literature | 2019 May

REPOSITORIES: biostudies-literature