Variable cellular decision-making behavior in a constant synthetic network topology.

ABSTRACT:

Background

Modules of interacting components arranged in specific network topologies have evolved to perform a diverse array of cellular functions. For a network with a constant topological structure, its function within a cell may still be tuned by changing the number of instances of a particular component (e.g., gene copy number) or by modulating the intrinsic biochemical properties of a component (e.g., binding strength or catalytic efficiency). How such perturbations affect cellular response dynamics remains poorly understood. Here, we explored these effects in a common decision-making motif, cross-antagonism with autoregulation, by synthetically constructing this network in yeast.

Results

We employed the engineering design strategy of reuse to build this topology with a

SUBMITTER: Shah NA 

PROVIDER: S-EPMC6515661 | biostudies-literature | 2019 May

REPOSITORIES: biostudies-literature