Liposomes for effective drug delivery to the ocular posterior chamber.

ABSTRACT:

Background

Age-related macular degeneration (AMD) is a leading cause of severe visual deficits and blindness. Meanwhile, there is convincing evidence implicating oxidative stress, inflammation, and neovascularization in the onset and progression of AMD. Several studies have identified berberine hydrochloride and chrysophanol as potential treatments for ocular diseases based on their antioxidative, antiangiogenic, and anti-inflammatory effects. Unfortunately, their poor stability and bioavailability have limited their application. In order to overcome these disadvantages, we prepared a compound liposome system that can entrap these drugs simultaneously using the third polyamidoamine dendrimer (PAMAM G3.0) as a carrier.

Results

PAMAM G3.0-coated compound liposomes exhibited ap

SUBMITTER: Lai S 

PROVIDER: S-EPMC6515668 | biostudies-literature | 2019 May

REPOSITORIES: biostudies-literature