Structural and Functional Reorganization of the Brain in Migraine Without Aura.

ABSTRACT: It remains unknown whether migraine headache has a progressive component in its pathophysiology. Quantitative MRI may provide valuable insight into abnormal changes in the migraine interictum and assist in identifying disrupted brain networks. We carried out a data-driven study of structural integrity and functional connectivity of the resting brain in migraine without aura. MRI scanning was performed in 36 patients suffering from episodic migraine without aura and 33 age-matched healthy subjects. Voxel-wise analysis of regional brain volume was performed by registration of the T1-weighted MRI scans into a common study brain template using the tensor-based morphometry (TBM) method. Changes in functional synchronicity of the brain networks were assessed using probabilistic independent compo

SUBMITTER: Soheili-Nezhad S 

PROVIDER: S-EPMC6515892 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature