What does sodium-glucose co-transporter 1 inhibition add: Prospects for dual inhibition.

ABSTRACT: Epithelial glucose transport is accomplished by Na⁺ -glucose co-transporters, SGLT1 and SGLT2. In the intestine, uptake of dietary glucose is for its majority mediated by SGLT1, and humans with mutations in the SGLT1 gene show glucose/galactose malabsorption. In the kidney, both transporters, SGLT1 and SGLT2, are expressed and recent studies identified that SGLT2 mediates up to 97% of glucose reabsorption. Humans with mutations in the SGLT2 gene show familial renal glucosuria. In the last three decades, significant progress was made in understanding the physiology of these transporters and their potential as therapeutic targets. Based on the structure of phlorizin, a natural compound acting as a SGLT1/2 inhibitor, initially several SGLT2, and later SGLT1 and dual SGLT1/2 inhibit

SUBMITTER: Dominguez Rieg JA 

PROVIDER: S-EPMC6516085 | biostudies-literature | 2019 Apr

REPOSITORIES: biostudies-literature