MTCH2 promotes adipogenesis in intramuscular preadipocytes via an m⁶A-YTHDF1-dependent mechanism.

ABSTRACT: Intramuscular fat is considered a potential factor that is associated with meat quality in animal production and insulin resistance in humans. N⁶-methyladenosine (m⁶A) modification of mRNA plays an important role in regulating adipogenesis. However, the effects of m⁶A on the adipogenesis of intramuscular preadipocytes and associated mechanisms remain unknown. Here, we performed m⁶A sequencing to compare m⁶A methylome of the longissimus dorsi muscles (LDMs) between Landrace pigs (lean-type breed) and Jinhua pigs (obese-type breed with higher levels of intramuscular fat). Transcriptome-wide m⁶A profiling of porcine LDMs was highly conserved with humans and mice. Furthermore, we identified a unique methylated gene in Jinhua pig

SUBMITTER: Jiang Q 

PROVIDER: S-EPMC6516144 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature