Hormone replacement therapy attenuates hearing loss: Mechanisms involving estrogen and the IGF-1 pathway.

ABSTRACT: Estradiol (E) is a multitasking hormone that plays a prominent role in the reproductive system, and also contributes to physiological and growth mechanisms throughout the body. Frisina and colleagues have previously demonstrated the beneficial effects of this hormone, with E-treated subjects maintaining low auditory brainstem response (ABR) thresholds relative to control subjects (Proceedings of the National Academy of Sciences of the United States of America, 2006;103:14246; Hearing Research, 2009;252:29). In the present study, we evaluated the functionality of the peripheral and central auditory systems in female CBA/CaJ middle-aged mice during and after long-term hormone replacement therapy (HRT) via electrophysiological and molecular techniques. Surprisingly, there are very few investi

SUBMITTER: Williamson TT 

PROVIDER: S-EPMC6516159 | biostudies-literature | 2019 Jun

REPOSITORIES: biostudies-literature