Increased intron retention is a post-transcriptional signature associated with progressive aging and Alzheimer's disease.

ABSTRACT: Intron retention (IR) by alternative splicing is a conserved regulatory mechanism that can affect gene expression and protein function during adult development and age-onset diseases. However, it remains unclear whether IR undergoes spatial or temporal changes during different stages of aging or neurodegeneration like Alzheimer's disease (AD). By profiling the transcriptome of Drosophila head cells at different ages, we observed a significant increase in IR events for many genes during aging. Differential IR affects distinct biological functions at different ages and occurs at several AD-associated genes in older adults. The increased nucleosome occupancy at the differentially retained introns in young animals suggests that it may regulate the level of IR during aging. Notably, an increase

SUBMITTER: Adusumalli S 

PROVIDER: S-EPMC6516162 | biostudies-literature | 2019 Jun

REPOSITORIES: biostudies-literature