Systemic clearance of p16^INK4a -positive senescent cells mitigates age-associated intervertebral disc degeneration.

ABSTRACT:

Rationale

Age-related changes in the intervertebral discs are the predominant contributors to back pain, a common physical and functional impairment experienced by older persons. Cellular senescence, a process wherein cells undergo growth arrest and chronically secrete numerous inflammatory molecules and proteases, has been reported to cause decline in the health and function of multiple tissues with age. Although senescent cells have been reported to increase in intervertebral degeneration (IDD), it is not known whether they are causative in age-related IDD.

Objective

The study aimed to elucidate whether a causal relationship exists between cellular senescence and age-related IDD.

Methods and results

To examine the impact of senescent cells on age-associated IDD, we

SUBMITTER: Patil P 

PROVIDER: S-EPMC6516165 | biostudies-literature | 2019 Jun

REPOSITORIES: biostudies-literature