Tau underlies synaptic and cognitive deficits for type 1, but not type 2 diabetes mouse models.

ABSTRACT: Diabetes mellitus (DM) is one of the most devastating diseases that currently affects the aging population. Recent evidence indicates that DM is a risk factor for many brain disorders, due to its direct effects on cognition. New findings have shown that the microtubule-associated protein tau is pathologically processed in DM; however, it remains unknown whether pathological tau modifications play a central role in the cognitive deficits associated with DM. To address this question, we used a gain-of-function and loss-of-function approach to modulate tau levels in type 1 diabetes (T1DM) and type 2 diabetes (T2DM) mouse models. Our study demonstrates that tau differentially contributes to cognitive and synaptic deficits induced by DM. On one hand, overexpressing wild-type human tau further e

SUBMITTER: Trujillo-Estrada L 

PROVIDER: S-EPMC6516168 | biostudies-literature | 2019 Jun

REPOSITORIES: biostudies-literature